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Health effects of hazardous substances

This course provides an introduction to health hazards caused by substances that are used at work. Basic toxicological terms and concepts (among others: dose response curves, toxicity testing), and types of health effects are explained. The biology and physiology of the most important human target organs and the possible routes and kinetics for toxic substances are clarified. A large variety of toxic substances is described, what their health effects can be, and where these hazardous substances are commonly used in industry. Some regulatory considerations are given and fundamental epidemiological knowledge is refreshed. Biological hazards are clarified in a separate chapter.



Original Authors:

Phil Johns, with help of others

Original affiliation, ownership:

Gully Howard Technical Limited, Portsmouth. Ownership is not strictly indicated, presumably: Occupational Hygiene Training Association (OHTA), Nottingham, UK

Year of publication:


Charge for use or free:

Free of charge


Target group(s):

graduate students, OSH experts; or in training

Usefulness for non-OSH-expert professionals:

More or less useful for non-OSH-expert professionals in health care or other sectors; or in training

Time demand to complete the lesson or course:

5 days


All aspects of basic human toxicology in an industrial setting are covered, including exposure routes and (mal)functioning of the organs.
This module is part of a program of modules designed for the education of occupational hygienists. Parts of this module can be useful for other disciplines.

Intellectual property and copyright:

Before downloading, changing, disseminating and/or using the lessons and courses, please look carefully at the conditions given by the authors or owners of the materials related to copyright or creative common conditions or other conditions for the downloading, changing, further dissemination and kind of use of the materials (non-commercial vs. commercial).

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